Gating the glutamate gate of CLC-2 chloride channel by pore occupancy

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Gating the glutamate gate of CLC-2 chloride channel by pore occupancy

CLC-2 channels are dimeric double-barreled chloride channels that open in response to hyperpolarization. Hyperpolarization activates protopore gates that independently regulate the permeability of the pore in each subunit and the common gate that affects the permeability through both pores. CLC-2 channels lack classic transmembrane voltage-sensing domains; instead, their protopore gates (residi...

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ژورنال

عنوان ژورنال: Journal of General Physiology

سال: 2015

ISSN: 1540-7748,0022-1295

DOI: 10.1085/jgp.201511424